Breathe Again Concentrated Decoction™

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Breathe Easy, Not Wheezy™

Originally crafted at the request of a Holistic Pediatrician, Breathe Again Concentrated Decoction™ has been trusted by physicians for over 27 years to support clear lungs, open airways, and comfortable breathing—for all ages. This smooth, great-tasting, all-natural formula is alcohol-free, kid-friendly, and 100% plant-based.

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Concentrated Decoction · Over the Counter
停止咳嗽免疫支持湯
Breathe Again™
Zhǐ Sòu Bù Zhèng Qì Tāng
Breathe Easy, Not Wheezy
27 Years in Service · 2+ Million Doses Delivered
A Cough Formula That Actually Tastes Good

Breathe Again™ was originally crafted at the request of a Holistic Pediatrician who needed something her young patients would actually take. The brief was simple: a formula that could stop coughs and clear infections in children — and that tasted good enough that parents wouldn’t have to fight to get it down. The result, refined over twenty-seven years and over 2 million doses delivered, is one of Si Jin Bao’s most-loved products and the over-the-counter version of our flagship A.I.R.™ professional formula — trusted by both Eastern and Western Physicians, and by the families they care for.

What makes Breathe Again different from a typical drugstore cough syrup is what’s not in it: no alcohol, no artificial sweeteners, no synthetic suppressants, no dyes. What’s in it is nine classical Chinese herbs in a vegetable glycerin base — the same nine-herb formulation a practitioner would use, made available without a prescription for families who already know it works.

The formula is alcohol-free, vegan, kid-friendly, and tastes good enough to take on its own. That last point matters more than it sounds: a cough formula a child won’t swallow doesn’t help anyone. That’s been the design constraint from day one, and it’s what’s made Breathe Again a household staple in homes that have used it across generations.

Coughs, Congestion, and Seasonal Misery

Breathe Again™ is built for the common upper-respiratory presentations that bring families to the medicine cabinet: coughs of all kinds, runny and stuffy noses, sinus pressure, post-viral lingering coughs that won’t quit, and the watery-itchy-eyes-and-sneezing miseries that come with seasonal allergies. The formula’s classical Chinese architecture — open the nose, resolve the phlegm, support the lungs, tone the immune foundation — addresses the underlying patterns that produce those symptoms rather than just suppressing them.

Common Uses
  • All types of cough · productive (with phlegm) and dry, tickly coughs
  • Stuffy nose, runny nose, sinus pressure
  • Sinus infections (including thick discoloured discharge)
  • Seasonal allergies · itchy and watery eyes, itchy nose, sneezing
  • Asthma support of all kinds
  • Post-viral lingering cough that doesn’t seem to go away
  • Recurring upper respiratory infections in kids
  • Certain types of urticaria (consult a healthcare practitioner first)
Open, Resolve, Support

Breathe Again™ works through three integrated layers, addressing what TCM calls Wind-Phlegm with Lung-Qi disharmony — the pattern beneath the cough, the cold, and the seasonal allergy.

Three nose-openersMagnolia Flower (Xin Yi Hua), Xanthium Fruit (Cang Er Zi), and Dahurian Angelica (Bai Zhi) — form the classical Chinese sinus-clearing trio. They open blocked nasal passages, drain trapped sinus pressure, and clear infection-related discharge. This is the layer that produces the rapid relief patients feel first.

Four phlegm-and-cough specialistsPlatycodon Root (Jie Geng), Magnolia Bark (Hou Po), Plantago Seed (Che Qian Zi), and Fresh Ginger (Sheng Jiang) — address the cough itself. They open the lungs, transform thick phlegm, drain damp downward, and harmonize the formula’s overall warmth. Together they handle everything from a wet productive cough to a tight wheezy chest to a dry tickly post-cold lingering cough.

Two foundational tonicsPsoralea Fruit (Bu Gu Zhi) and Glehnia Root (Bei Sha Shen) — support the deeper constitutional foundation. Psoralea helps the lungs grasp and hold the breath (the underlying support that prevents recurring respiratory weakness); Glehnia nourishes the lung’s natural moisture so the warming herbs don’t dry out the airways. Together they make Breathe Again appropriate for sustained use, not just acute episodes.

A Household Staple, Twenty-Seven Years In

Breathe Again™ is the kind of product families come back to season after season. Pediatricians have prescribed the professional version (A.I.R.) for over a quarter of a century; the over-the-counter version has delivered over 2 million doses through retail channels. Eastern and Western Physicians both reach for it. Families use it for kids’ first colds, for grandparents’ chronic seasonal congestion, and for the in-between cases where a practitioner visit isn’t necessary but a quality formula is.

What you’ll love about Breathe Again:

  • Promotes open airways and comfortable breathing
  • Supports healthy lung function and energy flow
  • Alcohol-free, kid-friendly, safe for all ages, and 100% plant-based
  • Designed for easy daily use — just add to hot water and sip warm
  • Pediatrician-designed, refined through twenty-seven years of continuous clinical and household use
  • Whole-pattern approach — addresses both symptoms and the underlying respiratory weakness, so it works for acute episodes AND ongoing seasonal support

A note on use: Breathe Again™ is a concentrated herbal decoction. See the Dosage Instructions tab for age-appropriate amounts (newborn through adult). If symptoms persist beyond a few weeks, worsen, or are accompanied by high fever, difficulty breathing, or other concerning signs, please consult your healthcare practitioner.

A.I.R.
Twenty-Seven Years on the Shelf · 2+ Million Doses Delivered

Breathe Again™ was built around a simple truth: a cough formula a child won’t take is a formula that doesn’t work. Twenty-seven years and over 2 million doses later, it remains one of the most-loved and most-trusted Si Jin Bao products — the kind of formula families keep on hand season after season, year after year. Because every breath should feel effortless.

Materia Medica · 本草
停止咳嗽免疫支持湯
Zhǐ Sòu Bù Zhèng Qì Tāng
Breathe Again™
Breathe Easy, Not Wheezy

Breathe Again™ is built on nine classical Chinese herbs in a vegetable glycerin base, structured around the architecture of opening the nose, resolving phlegm, descending Lung-Qi, and tonifying the foundational Yin and Yang. What follows is a full materia medica drawn from the Shen Nong Ben Cao Jing, Li Shizhen’s Ben Cao Gang Mu, and Bensky’s modern synthesis — with attention to each herb’s role in this specific formula.

01
Herb 01
生薑
Shēng Jiāng
Rhizoma Zingiberis Recens
Fresh Ginger Rhizome
Category
Warm, Acrid Herbs that Release the Exterior
Nature & Flavor
Acrid · Warm
Channels
Lung · Spleen · Stomach
Releases the exterior, disperses Cold, warms the middle and stops vomiting, transforms Phlegm and stops cough, harmonizes formulas. Sheng Jiang is one of the most foundational herbs in the materia medica — appearing in countless classical formulas as both an active herb and a harmonizer. In respiratory work, it warms the Lungs, transforms thin Phlegm-Cold, and stops cough.
Wind-Cold patterns at the exterior, productive cough with thin clear sputum, nausea and food stagnation in the Stomach, Phlegm-Cold patterns in the Lungs.
Recorded in the Shen Nong Ben Cao Jing. Classical authors prized Sheng Jiang as “the herb that returns Yang and harmonizes formulas” — a reference both to its warming nature and to its role coordinating other herbs in complex formulations. Zhang Zhongjing’s Shang Han Lun uses it across dozens of formulas.
Sheng Jiang warms the middle and harmonizes Breathe Again, preventing the formula’s overall character from becoming too cold or too cooling. Its ability to transform Phlegm-Cold complements Hou Po’s transformation of thicker Phlegm, while its harmonizing action ensures the cold and warm herbs work together rather than against each other.

02
Herb 02
桔梗
Jié Gěng
Radix Platycodi
Platycodon Root, Balloon Flower Root
Category
Herbs that Transform Phlegm & Stop Cough
Nature & Flavor
Bitter, acrid · Neutral
Channels
Lung
Opens the Lungs, transforms Phlegm, benefits the throat, expels pus, guides other herbs upward to the Lungs. Jie Geng is the classical “guide herb” for Lung-channel formulas — it floats the actions of other herbs upward to the chest and Lungs, ensuring the formula’s effect reaches where it needs to act. Its anti-inflammatory action on the throat makes it foundational for sore-throat-with-cough presentations.
Cough with copious phlegm, sore throat, hoarse voice, throat inflammation, lung abscess with productive pus, bronchitis with thick sputum.
Listed in the Shen Nong Ben Cao Jing. Classical authors observed that Jie Geng has an upward-floating nature that guides other herbs to the chest and throat — making it indispensable in respiratory formulas where the active herbs need to reach the Lungs rather than descend immediately to the lower burner.
Jie Geng is the formula’s directional anchor. Without an upward-floating guide herb, the warming and tonifying actives in Breathe Again would descend to the middle and lower burners rather than concentrating their action in the Lungs and throat. Jie Geng ensures the formula does its work where the respiratory pattern lives.

03
Herb 03
車前子
Chē Qián Zǐ
Semen Plantaginis
Plantago Seed
Category
Herbs that Drain Dampness
Nature & Flavor
Sweet · Cold
Channels
Kidney · Liver · Lung · Small Intestine
Drains Damp through urination, clears Heat, expels Phlegm, brightens the eyes. Che Qian Zi has a distinctive ability to drain Dampness from the upper burner downward through the urinary tract — making it useful in respiratory formulas where Phlegm-Damp needs an exit route. Its eye-brightening action also addresses the watery, itchy eyes that accompany many allergic presentations.
Phlegm-Damp obstructing the Lungs, productive cough with thick sputum, watery itchy eyes from Wind-Heat, allergic conjunctivitis, sinus congestion with damp character.
Recorded in the Shen Nong Ben Cao Jing as an upper-grade herb. Classical authors valued Che Qian Zi for its ability to drain Damp without damaging Yin — a quality that makes it appropriate for sustained use in chronic respiratory and allergy patterns where harsher draining herbs would deplete the patient.
Che Qian Zi opens a downward exit route for the Phlegm-Damp that Breathe Again is breaking up. Without a draining herb, the transformed Phlegm has nowhere to go — Che Qian Zi sends it through the urinary tract while simultaneously addressing the watery-eye component of allergic presentations.

04
Herb 04
厚朴
Hòu Pò
Cortex Magnoliae Officinalis
Magnolia Bark
Category
Aromatic Herbs that Transform Damp
Nature & Flavor
Bitter, acrid · Warm, aromatic
Channels
Spleen · Stomach · Lung · Large Intestine
Promotes movement of Qi, transforms Damp and dries Phlegm, descends rebellious Qi, stops asthma and cough. Hou Po is one of the most documented Phlegm-transforming herbs in the materia medica, with a particular ability to descend rebellious Lung-Qi — the upward-rebellion of Qi that produces wheezing, asthma, and the sensation of fullness in the chest.
Asthma and wheezing, cough with thick phlegm, chest fullness from Phlegm-Qi stagnation, rebellious Lung-Qi, productive bronchitis.
Listed in the Shen Nong Ben Cao Jing. Zhang Zhongjing used Hou Po in Hou Po Ma Huang Tang and Ban Xia Hou Po Tang — classical formulas for asthma and Phlegm-Qi obstruction respectively. The herb’s reputation for descending rebellious Lung-Qi has been continuous from the Han dynasty forward.
Hou Po is Breathe Again’s primary Phlegm-transforming herb. Where Sheng Jiang handles thin Phlegm-Cold and Che Qian Zi drains Damp downward, Hou Po breaks up the thick stagnant Phlegm that produces chest fullness, asthma, and difficult-to-clear cough.

05
Herb 05
補骨脂
Bǔ Gǔ Zhī
Fructus Psoraleae
Psoralea Fruit
Category
Tonifying Herbs — Yang Tonics
Nature & Flavor
Acrid, bitter · Very warm
Channels
Kidney · Spleen
Tonifies Kidney Yang, strengthens the Lungs’ grasp of the Qi, warms the Spleen and stops diarrhea. Bu Gu Zhi has a distinctive Kidney-Lung axis action: it tonifies Kidney Yang in a way that specifically supports the Lungs’ ability to grasp and root the Qi — addressing the underlying constitutional component of asthma and chronic wheezing presentations.
Asthma from Kidney failing to grasp the Qi, chronic wheezing in patients with constitutional Yang deficiency, recurrent wheezing in children with weak underlying Qi, cold-pattern respiratory weakness.
Recorded in classical pharmacopeia from the Tang dynasty forward. Classical authors paired Bu Gu Zhi specifically with respiratory formulas where the wheezing or chronic asthma had a constitutional component — recognizing that some respiratory patterns root in Kidney deficiency rather than in the Lungs alone.
Bu Gu Zhi is the constitutional anchor of Breathe Again. While the other herbs address the active respiratory pattern, Bu Gu Zhi addresses the underlying Kidney-Yang foundation that allows the Lungs to grasp the Qi — supporting deeper tissue function and preventing the chronic recurrence that defines pediatric and adult asthma alike.

06
Herb 06
北沙參
Běi Shā Shēn
Radix Glehniae
Glehnia Root, Northern Sand Root
Category
Tonifying Herbs — Yin Tonics
Nature & Flavor
Sweet, slightly bitter · Slightly cold
Channels
Lung · Stomach
Nourishes Lung Yin, generates fluids, clears empty Heat from the Lungs, supports Stomach Yin. Bei Sha Shen is the foundational Yin tonic for the Lungs — it nourishes the fluid that lines the airways, prevents dryness from over-warming herbs, and clears the empty Heat that develops in chronic respiratory patterns where Yin has been depleted.
Dry cough from Lung Yin deficiency, post-viral lingering dry cough, hoarse voice, dry mouth and throat, chronic dryness from heat-clearing or Phlegm-resolving formulas.
Listed in classical pharmacopeia. Classical authors paired Bei Sha Shen with warming and Phlegm-resolving formulas to prevent the over-drying that those herbs can produce — recognizing that respiratory tissues need moisture to function and that aggressive drying eventually depletes the Yin that supports Lung function.
Bei Sha Shen pairs with Bu Gu Zhi as the tonifying foundation. Where Bu Gu Zhi tonifies Yang for the lungs to grasp the Qi, Bei Sha Shen nourishes the Yin that keeps the airways moist and protected. Together they prevent the warming/transforming herbs from depleting the patient over sustained use — a critical consideration in pediatric patients and chronic-condition adults.

07
Herb 07
蒼耳子
Cāng Ěr Zǐ
Fructus Xanthii
Xanthium Fruit, Cocklebur
Category
Warm, Acrid Herbs that Release the Exterior
Nature & Flavor
Acrid, bitter · Warm (slightly toxic when raw — processed for medicinal use)
Channels
Lung
Opens the nasal passages, dispels Wind-Damp, alleviates pain, releases the exterior. Cang Er Zi is the classical herb of choice for nasal congestion of any pattern — Wind-Cold, Wind-Heat, allergic, or chronic. Its specific affinity for the nose makes it foundational for any formula addressing sinusitis, rhinitis, or chronic nasal obstruction.
Nasal congestion, sinusitis, allergic rhinitis, chronic post-nasal drip, headache from nasal obstruction, sinus pressure.
Recorded in the Shen Nong Ben Cao Jing. The classical formula Cang Er Zi San — paired with Xin Yi Hua and Bai Zhi — is the foundational sinus-clearing prescription in Chinese medicine, used continuously for over a thousand years for chronic nasal congestion patterns.
Cang Er Zi is one of three nose-opening herbs in Breathe Again, paired with Xin Yi Hua and Bai Zhi to recreate the classical Cang Er Zi San trio architecture. This trio is what gives the formula its rapid effect on nasal congestion and sinus pressure — the symptoms patients feel most acutely.

08
Herb 08
白芷
Bái Zhǐ
Radix Angelicae Dahuricae
Dahurian Angelica Root
Category
Warm, Acrid Herbs that Release the Exterior
Nature & Flavor
Acrid · Warm
Channels
Lung · Stomach · Large Intestine
Releases the exterior, dispels Wind, opens the nasal passages, drains pus, alleviates pain. Bai Zhi is distinctive among the nose-opening herbs for its ability to drain pus — making it the herb of choice for sinusitis with infection, where thick yellow or green discharge indicates accumulation that needs an exit route.
Sinus infection with thick discharge, frontal headache from sinus congestion, toothache from gum infection, nasal congestion with pus, chronic recurring sinusitis.
Listed in the Shen Nong Ben Cao Jing. Li Shizhen’s Ben Cao Gang Mu describes Bai Zhi as “the herb that opens the nine orifices of the head” — reflecting its broad action across the nose, sinuses, eyes, and gums. Its specific pus-draining action distinguishes it from other Wind-dispelling herbs.
Bai Zhi adds the pus-draining and infection-clearing dimension to the nose-opening trio. Cang Er Zi and Xin Yi Hua open the passages; Bai Zhi clears the underlying infection that produces sinusitis with thick discharge. Without Bai Zhi, Breathe Again could open the nose without addressing the bacterial component of sinus infection.

09
Herb 09
辛夷花
Xīn Yí Huā
Flos Magnoliae
Magnolia Flower Bud
Category
Warm, Acrid Herbs that Release the Exterior
Nature & Flavor
Acrid · Warm
Channels
Lung · Stomach
Disperses Wind-Cold, opens the nasal passages. Xin Yi Hua is a focused, single-purpose herb — its action is almost entirely on the nose. The flower bud’s distinctive volatile oils have a direct opening effect on the nasal mucosa, producing the rapid relief from congestion that characterizes the herb’s clinical use.
Nasal congestion, blocked nose, allergic rhinitis, chronic nasal obstruction, headache from nasal blockage, loss of smell from chronic congestion.
Recorded in the Shen Nong Ben Cao Jing as an upper-grade herb. Classical formularies pair Xin Yi Hua with Cang Er Zi as the foundational nose-opening duo — a combination so specific to nasal work that Cang Er Zi San takes its name from the pair plus Bai Zhi.
Xin Yi Hua completes the nose-opening trio with Cang Er Zi and Bai Zhi. Its volatile-oil action gives Breathe Again the rapid-onset nasal relief that patients feel within minutes of taking the formula — the immediate relief that builds compliance, particularly in pediatric work.

P1
Preparation Ingredient
蔬菜甘油
Shūcài Gānyóu
Glycerinum Vegetabile
Vegetable Glycerin
Purpose
Carrier & Sweetener
Source
Plant-derived, food-grade
Properties
Sweet · Neutral · Naturally palatable
Why Glycerin, Not Alcohol
Breathe Again is alcohol-free by design. Vegetable glycerin serves as the carrier and natural sweetener — producing the good-tasting, kid-friendly profile that makes the formula viable for pediatric work where compliance is the limiting factor. The glycerin extracts and stabilizes a meaningful range of the herbal actives while remaining safe for newborns, children, pregnant women, and patients who cannot or should not consume ethanol.

P2
Preparation Ingredient
蒸馏水
Zhēng Liú Shuǐ
Aqua Destillata
Distilled Water
Purpose
Extraction Medium
Source
Purified, pharmaceutical-grade
Properties
Neutral · Free of contaminants
Extraction & Concentration
Distilled water serves as the primary extraction medium for the water-soluble actives in the nine herbs. The concentrated decoction is then stabilized in vegetable glycerin for shelf-stable delivery. The pharmaceutical-grade water ensures the formula’s therapeutic action comes from the herbs alone, with no contaminants or mineral interference.

Breathe Again
Nine Herbs, Three Layers, One Formula

Each herb in Breathe Again addresses one component of the Wind-Phlegm-Lung-Qi pattern: Xin Yi Hua, Cang Er Zi, and Bai Zhi open the nose; Jie Geng, Hou Po, Che Qian Zi, and Sheng Jiang resolve and descend Phlegm; Bu Gu Zhi and Bei Sha Shen tonify the Yang and Yin foundation. Together they cover acute presentation, active disease process, and underlying constitutional support — in a single concentrated decoction that has been delivered over 2 million times across twenty-seven years of household and clinical use, trusted by both Eastern and Western Physicians.

Dosage & Preparation · 用法用量
How to Prepare & Dose

Si Jin Bao Over-the-Counter Concentrated Decoctions™ are activated in hot water, steeped briefly, and taken warm. Follow the four steps below, then refer to the age-appropriate dosing grid.

The Four Steps
  1. Step 01

    Shake
    Shake the bottle well before each use.
  2. Step 02

    Add Hot Water
    Add the age-appropriate dosage into 1 oz of hot water, as you would for tea.
  3. Step 03

    Steep
    Cover and steep for 5 minutes, then allow to cool to a warm, drinkable temperature.
  4. Step 04

    Drink
    Drink warm, twice daily or as directed by your practitioner.
For best results: take on an empty stomach — approximately 30 minutes before or after food or drink.
By Age Group
Newborn
15drops
Twice daily
1 Year
30drops
Twice daily
2–6 Years
40drops
Twice daily
Suggested Clinical Course
Acute
10 Days
Then Reevaluate
Subacute
30 Days
Then Reevaluate
Chronic
90 Days
Then Reevaluate
Bottle Longevity
11½ days
at standard adult dosage

Breathe Again CD OTC Product Sheet by SJB Team

Research · 研究
停止咳嗽免疫支持湯
Zhǐ Sòu Bù Zhèng Qì Tāng
Peer-Reviewed Evidence
Six Studies on the Herbs in Breathe Again™

What follows is peer-reviewed research on the principal active herbs in Breathe Again™. The six studies below are drawn from major journals and represent the kind of evidence Eastern and Western Physicians both look at when considering an herbal formula for clinical use. Citations are provided for those who want to verify or read further.

01
Study 01
蒼耳子散
Cang-Er-Zi-San in Pediatric Allergic Rhinitis
Meta-Analysis & Systematic Review
Medicine (Baltimore) · 2024
Design
Systematic review & meta-analysis of RCTs
Population
Children with allergic rhinitis
Relevance
Direct — CEZS herbs are the sinus-trio core of Breathe Again
Cang-Er-Zi-San (CEZS) is the classical Chinese formula composed of Cang Er Zi (Xanthium fruit), Xin Yi (Magnolia flower), Bai Zhi (Angelica dahurica), and peppermint — used in continuous clinical practice for over a thousand years for nasal congestion, allergic rhinitis, and sinusitis. This 2024 meta-analysis evaluated the formula’s efficacy and safety specifically in pediatric AR, where parental concern about steroid and antihistamine adverse events is highest.
The review found that Xanthium sibiricum (Cang Er Zi) stabilizes mast cell membranes, reducing the production of allergenic mediators and the release of intracellular substances — producing the anti-allergic effect clinically observed. The formula was shown to reduce expression of Th2 cytokines including IL-4, IL-5, and IL-13. Animal studies cited within the review demonstrated that Xanthium nasal-drop therapy effectively reduces AR-related behaviors (nose-scratching, sneezing) and restores body weight in mice, while contracting nasal mucosal blood vessels to reduce congestion.
Three of the four CEZS herbs (Cang Er Zi, Xin Yi Hua, Bai Zhi) form the nose-opening core of Breathe Again This meta-analysis provides modern evidence supporting the same architecture Breathe Again uses for nasal congestion, allergic rhinitis, and sinusitis — with particular relevance to Breathe Again’s pediatric-first design origin.
Evaluation of the efficacy and safety of Chinese medicine Cang-Er-Zi-San in the treatment of allergic rhinitis in children: A meta-analysis and systematic review. Medicine (Baltimore). 2024. PMCID: PMC11666178.

02
Study 02
鼻炎
Chinese Herbal Medicines for Rhinosinusitis
Text-Mining & Comparative Analysis
Chinese Medicine · 2025
Design
Text-mining of classical formulae & modern RCT comparison
Scope
436 oral formulae, 112 classical pharmacopoeia citations, modern RCTs
Relevance
Confirms Breathe Again’s core architecture in continuous use since Song dynasty
This 2025 text-mining study analyzed 436 classical oral formulae for rhinosinusitis (mean 7 ingredients per formula, 3,059 total ingredients) alongside 112 classical pharmacopoeia citations and modern randomized controlled trials — tracing herb usage patterns from the Song dynasty (960–1279 CE) through the early twentieth century and into contemporary clinical guidance.
The five most frequently used ingredients in classical oral formulae for rhinosinusitis were Magnolia spp. (Xin Yi Hua, n=162), Angelica dahurica (Bai Zhi, n=152), Glycyrrhiza spp. (Gan Cao, n=143), Xanthium sibiricum (Cang Er Zi, n=135), and Mentha spp. (Bo He, n=135). In the 112 classical pharmacopoeia citations specifically, the most frequent were Magnolia spp. (Xin Yi Hua, n=16), Xanthium sibiricum (Cang Er Zi, n=14), Angelica dahurica (Bai Zhi, n=13), and Piper longum (Bi Ba, n=12). Three of these four most-frequent classical herbs remain listed in the modern Chinese pharmacopoeia for bi yuan (sinus-related conditions).
Breathe Again is built on the three most-frequent classical-formula ingredients for rhinosinusitis (Xin Yi Hua, Bai Zhi, Cang Er Zi) — an architecture validated by both centuries of classical clinical practice and modern pharmacopoeia inclusion. The formula is not derivative; it sits within the documented mainstream of Chinese respiratory medicine.
Chinese herbal medicines for rhinosinusitis: a text-mining study with comparisons to contemporary research and clinical guidance. Chinese Medicine. 2025. PMCID: PMC12054199.

03
Study 03
厚朴
Magnolia officinalis (Houpo) & Constituents
Comprehensive Pharmacology & Toxicity Review
Frontiers in Pharmacology · 2017
Design
Comprehensive biological activity review
Active Compounds
Magnolol & honokiol (neolignan biphenyls)
Relevance
Anti-asthma & bronchodilator mechanisms
Magnolia officinalis (Hou Po) bark contains magnolol and honokiol as principal phenolic constituents — two neolignan biphenyl compounds responsible for the herb’s documented respiratory and anti-inflammatory action. The review synthesized over 250 isolated compounds from the genus Magnolia and their pharmacological mechanisms.
The review documented two distinct mechanisms by which Magnolia officinalis acts on asthma. First, the herb inhibits human lymphocyte blastogenesis in a dose-dependent manner, producing an anti-asthmatic effect through suppression of type IV (lymphocyte-mediated) allergic reactions. Second, magnolia extracts induce bronchodilatation via muscle relaxation associated with a calcium-channel antagonist effect — attributable principally to magnolol and honokiol. Alkaloids including (R)-coclaurine and (S)-reticuline additionally inhibit acetylcholine-induced muscle contraction.
Hou Po is Breathe Again’s primary phlegm-transforming and Lung-Qi-descending herb, addressing the rebellious-Qi component that produces wheezing and chest fullness. The dual-mechanism action documented in this review — lymphocyte-mediated allergy suppression plus calcium-channel-mediated bronchodilation — supports both the anti-allergy and the anti-asthma indications listed for the formula.
Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents. Frontiers in Pharmacology. 2017. PMCID: PMC5365644.

04
Study 04
桔梗
Platycodon grandiflorum (Jiegeng)
Ethnopharmacology & Phytochemistry Review
Journal of Ethnopharmacology · 2024
Design
Comprehensive review — 219 chemical constituents catalogued
Active Compounds
Platycodin D, polysaccharides, flavonoids
Relevance
Antitussive & expectorant pharmacology
Platycodon grandiflorum (Jie Geng) has been documented as both medicine and food in Chinese, Korean, and Japanese traditions for over a thousand years — with its primary clinical use centered on cough, phlegm, sore throat, and pulmonary conditions. The 2024 review identified 219 chemical constituents including 89 saponins, 11 flavonoids, 21 polysaccharides, 14 phenolic acids, and additional minor components.
Among 17 chemical components evaluated for expectorant activity, platycosides D2, Platycodin D (PD), and polysenoside D2 ranked highest. Twelve components of Jiegeng were associated specifically with antitussive activity. Components such as polygalacin D, deapioplatycodin D, and Platycodin D showed strong antitussive activity but lower expectorant action, while platycosides D3, G3, and PD demonstrated both antitussive and expectorant effects in combination. In vitro studies showed mucin production in airway epithelial cells (RTSE cells) increased by 252.7% with Platycodin D and 370.2% with platycodin D3 at 200 mg/L — supporting the herb’s classical reputation as an active expectorant.
Jie Geng is Breathe Again’s upward-floating guide herb — the directional anchor that ensures the formula’s other actives reach the Lungs and throat. Its dual antitussive-and-expectorant action documented in this review supports both the cough-stopping and the phlegm-clearing indications that define the formula’s clinical breadth.
Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: A review. Journal of Ethnopharmacology. 2024. PMCID: PMC11283231.

05
Study 05
補骨脂
Psoralea corylifolia (Bu-gu-zhi)
Comprehensive Pharmacology Review
Chinese Medicine · 2023
Design
Comprehensive review — 163 chemical components catalogued
Active Compounds
Psoralen, bavachalcone, coumarins, flavonoids
Relevance
Lung-grasping-Qi action & chronic asthma support
Psoralea corylifolia (Bu Gu Zhi) was first described in Lei’s Treatise on Preparing Drugs during the Northern and Southern Dynasties (420–581 CE) and has been continuously used since. The 2023 review catalogued approximately 163 chemical components including coumarins, flavonoids, monoterpene phenols, benzofurans, glycosides, lipids, fatty acids, and volatile oils — documenting pharmacological activities including anti-inflammatory, antibacterial, antiviral, antioxidant, and immunomodulatory effects.
The review confirmed Psoralea’s classical action of reinforcing Kidney Yang, helping inspiration, and relieving asthma — the TCM mechanism for what Bensky’s materia medica describes as “the Lungs’ grasp of the Qi.” Classical formulas including Buguzhi Pills paired psoralen with cinnamon for asthma caused by Kidney deficiency. The review additionally documented Psoralea’s role as a primary ingredient in Gunben Kechuan Pian, a clinically used preparation for chronic bronchitis, emphysema, and bronchial asthma per modern Chinese pharmacopoeia.
Bu Gu Zhi is Breathe Again’s constitutional anchor for chronic and recurrent respiratory presentations. Its documented Kidney-Lung axis action — tonifying the Kidney Yang that supports the Lungs’ grasp of the Qi — addresses the underlying constitutional component of asthma and chronic wheezing that purely surface-level treatment cannot reach.
Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics. Chinese Medicine. 2023. PMCID: PMC9830135.

06
Study 06
白芷
Angelica dahurica (Bai Zhi)
Traditional Uses, Phytochemistry & Pharmacology Review
Frontiers in Pharmacology · 2022
Design
Comprehensive review — 300+ chemical constituents catalogued
Active Compounds
Coumarins (imperatorin, isoimperatorin), volatile oils
Relevance
Anti-inflammatory, antimicrobial & sinus-clearing actions
Angelica dahurica (Bai Zhi) has been used in China for thousands of years as both food and traditional medicine. Modern phytochemical investigation has identified over 300 chemical constituents, with coumarins (notably furanocoumarins including imperatorin, isoimperatorin, oxypeucedanin, and byakangelicin) and volatile oils representing the major active classes. Classical sources from Ben Cao Gang Mu (Ming dynasty, 1368–1644) onward document Bai Zhi specifically for nasosinusitis (鼻渊, bi yuan).
The review documented Bai Zhi and its active components as exhibiting anti-inflammatory, anti-microbial, antiviral, analgesic, anti-tumor, anti-oxidation, neuroprotective, and hepatoprotective bioactivities — with the anti-inflammatory and antimicrobial mechanisms most relevant to its classical use for sinus infection. The volatile oil fraction’s terpenes were shown to influence local blood flow and microbial balance in the upper airway, while the furanocoumarins exhibited documented anti-inflammatory and analgesic activity in lab and animal studies.
Bai Zhi is the third member of Breathe Again’s nose-opening trio — specifically chosen for its pus-draining and infection-clearing action that distinguishes it from purely Wind-dispelling herbs. Its documented antimicrobial and anti-inflammatory actions support Breathe Again’s indication for sinusitis with thick discharge, where opening the nasal passages alone would address only the surface symptom without clearing the infection beneath.
The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology. Frontiers in Pharmacology. 2022. PMCID: PMC9283917.

BA
Tradition Meets Mechanism

The research supports what Eastern and Western Physicians have been observing for twenty-seven years — and what classical Chinese physicians documented over the millennium before that. The Cang Er Zi San trio opens the nose through documented mast-cell stabilization and Th2 cytokine modulation. Magnolol and honokiol bronchodilate via calcium-channel mechanisms. Platycodin D drives the antitussive and expectorant action. Psoralea anchors the constitutional foundation that allows the Lungs to grasp the Qi. Bai Zhi clears the bacterial component beneath sinus presentations. Six herbs, six mechanisms, one formula — built on architecture documented continuously since the Song dynasty, and carried forward through over 2 million doses delivered across twenty-seven years of household and clinical use.

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